Ehab Sarsour , PhD
Aging Related Research:
My research interest focuses on the molecular mechanisms that regulate regenerative properties of normal and cancer quiescent cells. I proposed that two separate but interdependent pathways could regulate cellular longevity: a redox-sensitive checkpoint regulating transition from quiescence (G0/G1) to proliferation (S) also known as chronological life span followed by telomeric attrition controlling the “mitotic clock” known as replicative life span. My research has shown that the antioxidant enzyme manganese superoxide dismutase protects quiescent normal human fibroblast regenerative capacity (chronological life span) by regulating mitochondrial reactive oxygen species and protecting mitochondrial morphology from age associated abnormalities. My work has evolved into examining the molecular mechanisms associated with oxidative stress and inflammation during cellular aging. The scope of my current and future work is to understand how cellular redox status and reactive oxygen species regulate quiescent cells biology in human tissue and their effect on the microenvironment of diseased tissue during aging.
Keywords: Quiescence, reactive oxygen species, chronological life span, mitochondria, metabolism